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Morphological development of human hippocampus: cross-sectional and longitudinal studies by high-resolutionmagnetic resonance imaging

人类海马体的形态发育：高分辨率磁共振成像的横断面和纵向研究

基本信息

批准号：
16500215
负责人：
SUZUKI Michio
金额：
$ 2.29万
依托单位：
University of Toyama (2005-2007)Toyama Medical and Pharmaceutical University (2004)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2007
项目状态：
已结题

项目摘要

Morphological development of human hippocampus and related brain regions and its implications in the pathophysiology of schizophrenia were investigated using magnetic resonance imaging (MRI).1. Volumes of the hippocampus and the amygdala were significantly larger in male elder adolescents than in male younger adolescents. These results suggest a robust maturational process ongoing in the human hippocampus and amygdala during adolescence, especially in males, which maybe relevant to progress in myelination.2. Volumetric analyses demonstrated that, in patients with schizotypal disorder, volumes of the amygdala and hippocampus were significantly reduced, whereas prefrontal volumes were preserved. Shizophrenia patients had significant volume reductions in the prefrontal areas as well as in the amygdala and hippocampus. These findings suggest that volume reductions in the amygdala and hippocampus may represent the vulnerability, whereas additional widespread involvement of the prefrontal cortex in schizophrenia may play critical roles in the manifestation of overt psychosis.3. Structural abnormalities in the cerebral midline structures such as the cavum septi pellucidi (CSP) and the adhesio interthalamica (AI), and their relation with the volumes of the medial temporal structures were explored in schizophrenia patients. The patients with a large CSP had smaller volumes of bilateral amygdala and left posterior parahippocampal gyrus than those without it. The patients without an AI had a smaller bilateral amygdala than those with an AL These findings suggest that the abnormalities in the cerebral midline structures and the medial temporal lobe regions may reflect developmental disturbance in the neural network including the midline and associated limbic structures of the brain in schizophrenia.

本研究应用磁共振成像技术（MRI）研究了精神分裂症患者海马及相关脑区的形态发育及其病理生理学意义.老年男性青少年海马和杏仁核的面积显著大于青年男性青少年。这些结果表明，在青春期，尤其是男性，海马和杏仁核中正在进行一个强大的成熟过程，这可能与髓鞘形成的进展有关。体积分析表明，在患者中，杏仁核和海马体积显着减少，而前额叶体积保存。希氏症患者的前额区、杏仁核和海马体体积显著减少。这些发现表明杏仁核和海马体的体积减少可能代表了脆弱性，而精神分裂症患者前额叶皮层的额外广泛参与可能在显性精神病的表现中发挥关键作用。探讨精神分裂症患者大脑中线结构如透明隔腔（CSP）和丘脑间粘连（AI）的结构异常及其与内侧颞叶结构体积的关系。大CSP组双侧杏仁核和左侧海马旁后回体积小于无CSP组，无AI组双侧杏仁核体积小于AL组。这些结果提示，大脑中线结构和内侧颞叶区的异常可能反映了包括中线和相关边缘结构在内的神经网络的发育障碍。精神分裂症

项目成果

期刊论文数量（20）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

統合失調症の脆弱性と発症に関わる脳形態の変化について.

大脑形态的变化与精神分裂症的脆弱性和发病有关。

DOI：
发表时间：
2006
期刊：
社会精神医学会雑誌 15
影响因子：
0
作者：
鈴木道雄;高橋努;周世いく;ら
通讯作者：
ら

Medial temporal volume reduction as a vulnerability marker for schizophrenia

内侧颞叶体积减少是精神分裂症的脆弱性标志

DOI：
发表时间：
2005
期刊：
影响因子：
0
作者：
Suzuki;M.;Hagino;H.;Niu;L.;Zhou;S.Y.;Takahashi;T.;Kawasaki;Y.;Matsui;M.;Kurachi;M
通讯作者：
M

Male-specific volume expansion of the human hippocampus during adolescence

DOI：
10.1093/cercor/bhh121
发表时间：
2005-02-01
期刊：
CEREBRAL CORTEX
影响因子：
3.7
作者：
Suzuki, M;Hagino, H;Kurachi, M
通讯作者：
Kurachi, M

Association between absence of the adhesio interthalamica and amygdala volume in schizophrenia.

精神分裂症中丘脑间粘连缺失与杏仁核体积之间的关联。

DOI：
发表时间：
2008
期刊：
Psychiatry Res. 162
影响因子：
0
作者：
Takahashi T.;Suzuki M.;Nakamura K.;Tanino R.;Zhou S. Y.;Hagino H.;Niu L.;Kawasaki Y.;Seto H.;Kurachi M.
通讯作者：
Kurachi M.

統合失調症の脳形態学的研究-病態形成との関わりと客観的診断法への応用-.

精神分裂症的脑形态学研究 - 与发病机制的关系及其在客观诊断方法中的应用。