Correlation between neuromelanin cell density and MR signal intensity : evaluation by autoasied brains and 3 tesla MR imaging

为了阐明神经黑色素成像（NMI）的组织病理学背景，我们对尸检的胎儿进行了NMI-病理学相关性研究。我们还使用99 mTc-ECD单光子发射CT评估了NMI患者的脑血流。NMI较好地反映了中脑黑质含神经黑素神经元的数量。NMI信号强度降低的患者在楔前叶、楔叶和扣带回后部的局部脑血流量明显降低。

To clarify the histopathological background of neuromelanin imaging (NMI), we performed NMI-pathologic correlations of autopsied btrains. We also evaluated cerebral blood flow using single photon emission CT with 99mTc-ECD in patients undertaken NMI. NMI well reflected amount of neuromelanin-containing neurons of the substantia nigra of the midbrain. Patients with decreased signal intensity in NMI showed significantly lower regional cerebral blood flow in the precuneus, cuneus, and posterior part of the cingulate gyrus.