Distant Secondary Degeneration: Quantitative Evaluation of Neuron Density by 3 Tesla MRI and SPECT

远端继发性变性:通过 3 特斯拉 MRI 和 SPECT 定量评估神经元密度

基本信息

  • 批准号:
    17591270
  • 负责人:
  • 金额:
    $ 2.43万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2005
  • 资助国家:
    日本
  • 起止时间:
    2005 至 2007
  • 项目状态:
    已结题

项目摘要

I-123 iomazenil has favorable characteristics for in vivo assessment of benzodiazepine receptors with single photon emission computed tomography (SPECT). Using this ligand, we studied the central benzodiazepine receptor distribution in the cerebral cortex in patients with unilateral basal ganglionic or thalamic hemorrhage. This study included fifteen patients (9 men, 6 women : mean age 67.8 yr) with hypertensive brain hemorrhage (10 and 5 patients with unilateral thalamic or basal ganglionic hemorrhage, respectively). SPECT images were obtained 12 to 21 days (mean : 13.7 days) after the onset of hemorrhage. We also performed diffusion tensor imaging to evaluate water diffusivity using 3 tesla MR imaging for 5 patients. Diffusion tensor imaging applied diffusion gradient encoding in six non-collinear directions. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were measured in the anterior and posterior cerebral white matter.On SPECT images, we evaluated the ac … More cumulation of I-123 iomazenil qualitatively and quantitatively. The accumulation of I-123 iomazenil in the ipsilateral cerebral cortex of the hemorrhage tended to be decreased in comparison with that of the contralateral cerebral cortex. However, the radioactivity ratio of the ipsilateral to the contralateral cerebral cortex (I/C ratio) was not significantly decreased. On the diffusion tensor imaging, ADC values of the ipsilateral cerebral white matter tended to be higher than those of the contralateral cerebral white matter.FA values of the ipsilateral cerebral white matter tended to be lower than those of the contralateral white matter. However, these changes were not statistically significant. Central benzodiazepine receptor I-123 iomazenil binding was decreased in the ipsilateral cerebral cortex remote from the hemorrhage. On the diffusion tensor imaging, water diffusivity of the ipsilateral cerebral white matter was different from contralateral cerebral white matter. These results would suggest the potential damage of the cortical neurons remote from thalamic or basal ganglionic hemorrhage. Less
I-123异马西尼可用于单光子发射计算机断层扫描(SPECT)对苯二氮卓类受体的体内评价。利用该配体,我们研究了单侧基底节或丘脑出血患者大脑皮层中枢苯二氮卓受体的分布。本研究包括15例高血压脑出血患者(男性9例,女性6例,平均年龄67.8岁),其中单侧丘脑或基底节出血患者分别为10例和5例。于出血后12~21天(平均13.7天)行SPECT显像。我们还使用3Tesla磁共振成像对5名患者进行了扩散张量成像以评估水的扩散率。扩散张量成像在六个非共线方向上采用扩散梯度编码。测量大脑前部和后部白质的表观扩散系数(ADC值)和各向异性分数(FA值)。在SPECT图像上,我们评估了Ac…I-123碘马西尼在定性和定量上的累积较多。I-123碘马西尼在出血侧大脑皮质的蓄积较对侧脑皮质有减少的趋势。而同侧与对侧大脑皮质放射性比值(I/C)无明显下降。在弥散张量成像上,同侧大脑白质的ADC值有高于对侧的趋势,FA值有低于对侧的趋势。然而,这些变化在统计上并不显著。中枢性苯二氮卓类受体I-123在远离出血的同侧大脑皮质中的结合减少。在弥散张量成像上,同侧脑白质的水扩散率与对侧脑白质不同。这些结果提示远离丘脑或基底节出血的皮质神经元可能受到损害。较少

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hyperintense putaminal rim at 3T reflects fewer ferritin deposits in the lateral marginal area of the putamen
3T 壳核边缘高信号反映壳核外侧边缘区域铁蛋白沉积较少
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Fujii S;Ogawa T;et. al.
  • 通讯作者:
    et. al.
Cerebral cortical and white matter lesions in amyotrophic lateral sclerosis with dementia: Correlation with MR and pathologic examinations
  • DOI:
    10.3174/ajnr.a0605
  • 发表时间:
    2007-09-01
  • 期刊:
  • 影响因子:
    3.5
  • 作者:
    Matsusue, E.;Sugihara, S.;Ogawa, T.
  • 通讯作者:
    Ogawa, T.
Cerebral cortical and white matter lesions in chronic hepatic encephalo pathy : MR-pathologic correlations
慢性肝性脑病的大脑皮质和白质病变:MR-病理相关性
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Matsusue E;Ogawa T;et al.
  • 通讯作者:
    et al.
Cerebral cortical and white matter lesions in chronic hepatic encephalopathy: MR-pathologic correlations
慢性肝性脑病的大脑皮质和白质病变:MR-病理相关性
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Matsusue E;Ogawa T;et al.
  • 通讯作者:
    et al.
Evaluation of cerebral benzodiazepine receptor distribution in cerebral hemorrhage by 123I-Iomazenil SPECT
123I-Iomazenil SPECT评价脑出血脑内苯二氮卓受体分布
  • DOI:
  • 发表时间:
    2007
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ishibashi M;Ogawa T;et al.
  • 通讯作者:
    et al.
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OGAWA Toshihide其他文献

OGAWA Toshihide的其他文献

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{{ truncateString('OGAWA Toshihide', 18)}}的其他基金

Fundamental and clinical study for the purpose of early diagnosis of multiple system atrophy
以早期诊断多系统萎缩为目的的基础和临床研究
  • 批准号:
    24591763
  • 财政年份:
    2012
  • 资助金额:
    $ 2.43万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Correlation between neuromelanin cell density and MR signal intensity : evaluation by autoasied brains and 3 tesla MR imaging
神经黑色素细胞密度和 MR 信号强度之间的相关性:通过自动大脑和 3 特斯拉 MR 成像进行评估
  • 批准号:
    20591444
  • 财政年份:
    2008
  • 资助金额:
    $ 2.43万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Research for Pathophysiology of Diffuse Cerebral White Matter Disease -Evaluation with MRI of Autopsied Brain and Diffusion Weighted MRI-
弥漫性脑白质疾病的病理生理学研究-尸检脑MRI和弥散加权MRI评估-
  • 批准号:
    10670850
  • 财政年份:
    1998
  • 资助金额:
    $ 2.43万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似国自然基金

高原地区藏汉民族正常成人与高原心脏病患者心脏结构和左右心室功能的3T MRI研究
  • 批准号:
    81260216
  • 批准年份:
    2012
  • 资助金额:
    49.0 万元
  • 项目类别:
    地区科学基金项目

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将临床组织微观结构成像作为大口径 3T MRI 的诊断工具
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