Impact of endocrine environment on the development, biological features and progression of prostate cancer.

西方化饮食导致的血清胆固醇浓度升高可能影响人体矿物质皮质醇浓度及随之而来的性激素环境变化。在本研究中，我们调查了血清性激素与前列腺癌发病的相关性。一项病例对照研究表明，与没有临床表现的前列腺癌患者相比，几年前诊断为前列腺癌的患者血清孕烯醇酮(P5)水平显著升高，而雌二醇和11-脱氧皮质酮水平显著降低。转换酶Cyp11a1的加速可能在导致这种特殊的内分泌特征和随后的癌症发展中起到一定的作用。

Increased serum cholesterol concentration due to westernized diet may affect mineral corticoids concentration and following changes in sex hormone environment in human. In the present study, we investigated correlation between serum sex hormones and promotion of prostate cancer. A case control study demonstrated that patients diagnosed with prostate cancer had significantly higher serum pregnenolone (P5) level and lower both estradiol and 11-deoxycorticosterone levels in the serum taken several years ago compared with men without clinically manifested prostate cancer. An acceleration of converting enzyme, CYP11A1, may play some role to lead such a specific endocrine feature and following cancer development.