Study on the expression of ion channels in inflammation-induced uterine smooth muscle elucidating the mechanisms of preterm delivery.

在妊娠大鼠子宫肌层中，S及其蛋白的定量检测表明，作为一种对三磷酸腺苷敏感的非选择性阳离子通道，P2X4和P2X7受体高表达。在新分离的妊娠大鼠子宫肌层细胞中观察到的NSCC电流与转导P2X7受体的COS7细胞中的NSCC电流相似，表明大鼠子宫肌层中的P2X7受体在NSCC电流的传导中起主要作用。这可能表明，通过P2X7流入的C^lt；2+可能会引发劳动力收缩。在脂多糖诱导的炎症模型大鼠子宫中，P2X7受体高表达。因此，这些结果表明炎症刺激大鼠子宫肌层中P2X7受体的表达可能导致早产。对这一主题的进一步研究应有助于阐明早产的确切机制，以及开发预防早产的新疗法和新技术。

In pregnant rat myometrium, P2X4 and P2X7 receptors, one of ATP-sensitive non-selective cation channels (NSCC), were suggested to be highly expressed by the quantitative evaluation of mRNA s and proteins. NSCC currents observed in freshly isolated cells from pregnant rat myometrium resembles to those from COS7 cells where P2X7 receptors were transfected, indicating P2X7 receptor in rat myometrium play a major role in conducting NSCC currents. It may be suggested that C^<2+> influx through P2X7 may trigger labor contraction. In uterus of inflammatory model rats induced by application of LPS (lipopolysaccharide), P2X7 receptors were highly expressed. Thus, these results indicate that stimulation of P2X7 receptor expression in rat myometrium induced by inflammation may lead to preterm delivery. Further study on this subject should contribute to the elucidation of precise mechanisms of preterm delivery as well as development of new therapies and new technologies of prevention against preterm delivery.