A study evaluating the effects of physical therapy on rat models of neuropathic pain based on electrophysiological parameters

基于电生理参数评估物理治疗对大鼠神经病理性疼痛模型影响的研究

• 批准号: 23650342
• 负责人: YAMAOKA Kaoru
• 金额: $ 2.41万
• 依托单位: Hiroshima International University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650342/
• 关键词: 慢性疼痛; 電位依存性Naチャネル; 後根神経節細胞; テトロドトキシン; 理学療法; 後根神経節; 神経因性疼痛; ラット; 電気生理学

Effects of physical therapy on the chronic pain model of rat induced by neuronal damage was tested by using exercise training (swimming), transcutaneous electrical reversed nerve stimulation (TENS) and whole-body vibration. TENS reversed lowered thermal pain threshold of rats induced by nerve constriction. In addition to neuronal damage of sciatic nerve, immobilization of ankle joint successfully established a chronic pain model. Alteration of electrophysiological property, such as increased expression of TTX-sensitive sodium channels, of sensory nerve (dorsal root ganglion neuron) innervating the injured limb was suspected.

采用运动训练（游泳）、经皮电逆神经刺激（TENS）和全身振动等方法，观察物理疗法对神经元损伤所致大鼠慢性疼痛模型的影响。TENS可逆转神经缩窄引起的大鼠热痛阈降低。除坐骨神经损伤外，踝关节制动成功地建立了慢性疼痛模型。怀疑支配损伤肢体的感觉神经（背根神经节神经元）的电生理特性改变，如TTX敏感性钠通道表达增加。