Development of the treatment for acute coronary syndrome by dental bacteria elimination

在174例急性冠脉综合征(ACS)患者中，58%的标本包括冠状动脉血和动脉粥样硬化斑块中检出牙龈假单胞菌DNA，这是牙周病(PD)的代表致病菌。此外，菌斑中来自细菌的一种蛋白水解酶--姜辣素的活性增加。虽然我们推测帕金森病的治疗可以预防急性冠脉综合征的蛋白酶诱导的斑块破裂，从而减少主要的不良心脏事件，但在平均14.8个月的预后研究中，样本中细菌的检测对急性冠脉综合征发病后6个月的事件发生率没有影响。

In 174 patients with acute coronary syndrome (ACS), the DNA of P. gingivalis, which is a representative responsible bacterium for periodontal disease (PD), was detected in 58% of the sample including the coronary artery blood and the atherosclerotic plaque. Moreover, the activity of Gingipain, which is a protease from the bacterium, increased in the plaque. Although we speculated that the treatment of PD can prevent the protease-induced plaque rupture for ACS and thereby reduce the major adverse cardiac event, the detection of the bacterium in the sample did not influence to the event rate at 6 months after the onset of ACS in the prognosis research for average 14.8 months.