Total analysis of Pax family genes in oral carcinoma.

在本研究中，为了确定PAX基因在口腔鳞状细胞癌（OSCC）中的潜在参与，我们通过实时定量逆转录-聚合酶链反应评估了PAX基因mRNA在OSCC细胞系中的表达状态。与人正常口腔角质形成细胞（HNOKs）相比，所有oscc来源的细胞系中PAX5的表达均显著增加。结果提示PAX5在口腔癌变过程中发挥重要作用，该基因可能具有作为OSCC生物标志物和治疗靶点的潜力。

In the current study, to determine the potential involvement of PAX genes in oral squamous-cell carcinoma (OSCC), we evaluated the status of PAX genes mRNA expression in OSCC cell lines, by real-time quantitative reverse transcriptase-polymerase chain reaction. A significant increase in PAX5 expression was observed in all OSCC-derived cell lines examined compared to human normal oral keratinocytes (HNOKs). The results suggest that PAX5 plays an important role during oral carcinogenesis, and that the gene may have potential as a biomarker and therapeutic target for OSCC.