Reverification of the mechanistic membrane effects of anesthetics : Interactions with biomembrane rafts and specific membrane lipids

除了传统的麻醉药与受体和通道特异性结合的机制外，我们基于最新的生物膜结构和功能理论，验证了麻醉药与生物膜相互作用的机制假设，以发挥临床有用和不利的作用。膜脂筏与麻醉剂的相关性至少在它们对筏样模型膜的影响方面是值得怀疑的。然而，麻醉剂与由特定脂质（胆固醇和阴离子磷脂）组成的仿生膜的相互作用是结构依赖的，它们的相互作用效力甚至在立体异构体之间也是区分的。这些结果支持麻醉药的膜相互作用作为作用模式。

Apart from the conventional mechanism in which anesthetics specifically bind to receptors and channels, we reverified the mechanistic hypothesis that anesthetics may interact with biomembranes to exert clinically useful and adverse effects based on the latest structural and functional theory about biomembranes. The relevance of membrane lipid rafts to anesthetics was questionable at least in their effects on raft-like model membranes. However, anesthetics structure-dependently interacted with biomimetic membranes consisting of specific lipids (cholesterol and anionic phospholipids) and their interacting potencies were discriminated even between stereoisomers. These results support the membrane interaction of anesthetics as the mode of action.