Development of an Attenuated Infectious Laryngotracheitis Virus Vaccine

该项目将开发新的方法来鉴定与重要的禽类病原体传染性喉气管炎病毒毒力相关的基因，并通过对病毒S基因组中的两个或两个以上基因进行特定破坏和缺失来生产减毒的、抗原性标记的传染性喉气管炎病毒疫苗株。 传染性喉气管炎是全世界鸡的一种主要疾病，但目前的疫苗仍具有一定的致病能力。因此，新型减毒疫苗的开发将加强对这一重要家禽疾病的控制。

This project will develop novel methods for identification of genes involved in virulence of the important avian pathogen Infectious Laryngotracheitis Virus and produce an attenuated, antigenically marked infectious laryngotracheitis virus vaccine strain by specific disruption and deletion of two or more genes in the virusÕs genome. Infectious laryngotracheitis is a major disease of chickens throughout the world, but current vaccines retain some capacity to cause disease. The development of novel attenuated vaccines will thus enhance control of this important disease of poultry.