Measurement of Mechanical Properties on Plasma Proteins and Computational Simulation of Primary Thrombosis Formation

我们开发了一种计算分析血小板粘附和聚集的方法，考虑到两种血浆蛋白的不同特性，vonWillebrand因子和纤维蛋白原。该方法采用Stokesian动力学方法模拟了简单剪切流动条件下血小板颗粒间的流体动力学相互作用。模拟了由冯氏血友病因子和纤维蛋白原介导的颗粒间结合力。

We developed a method to analyze platelet adhesion and aggregation computationally, taking into account the distinct properties of two plasma proteins, vonWillebrand factor and fibrinogen. In this method, the hydrodynamic interactions between platelet particles under simple shear flow were simulated using Stokesian dynamics. The binding force between particles mediated by vonWillebrand factor and fibrinogen was modeled.