Preventive effect of silk protein, sericin, on metabolic syndrome

本研究旨在探讨饲粮中添加丝胶对高脂饲料大鼠脂质和碳水化合物代谢的影响。丝胶蛋白的消耗显著降低了血清和肝脏的脂质以及脂肪生成酶的活性。膳食丝胶抑制腹腔注射葡萄糖后血浆葡萄糖和胰岛素水平的升高。膳食丝胶导致血清脂联素显著升高。这些结果表明，摄入丝胶蛋白增加血清脂联素，至少在一定程度上有助于对高脂饮食大鼠的高脂血症、脂肪肝和葡萄糖耐受不良的保护作用。食用丝胶蛋白可显著提高高脂日粮大鼠粪便免疫球蛋白A （IgA，肠道免疫功能指数）、粘蛋白（肠屏障功能指数）和盲肠有机酸。血清甘油三酯与盲肠醋酸酯呈负相关。这些结果表明丝胶蛋白是改善高脂饲料大鼠脂质和碳水化合物代谢和肠道环境的有用剂。

This study was performed to examine the effect of dietary sericin on the lipid and carbohydrate metabolisms in rats fed high-fat diet. Consumption of sericin significantly reduced serum and liver lipids and the activities of the lipogenic enzymes. Dietary sericin suppressed the increases in plasma glucose and insulin levels after intraperitoneal glucose injection. Dietary sericin caused a marked elevation in serum adiponectin. These results imply that the increase in serum adiponectin by sericin intake may, at least in part, contribute to the protective effect against hyperlipidemia, fatty liver and glucose intolerance in rats fed a high-fat diet. Consumption of sericin markedly elevated fecal immunoglobulin A (IgA, index of intestinal immune function), mucins (index of intestinal barrier function) and cecal organic aicds in rats fed the high-fat diet. There was an inverse correlation between serum triglyceride and cecal acetate. These results imply that sericin is a useful agent for improving lipid and carbohydrate metabolisms and intestinal luminal environments in rats fed a high-fat diet.