Bioactive interface based on electrochemical nano-processing

基于电化学的生物光刻技术被集成到普通原子力显微镜(AFM)配置中，以绘制蛋白质和活细胞的图案。图案化过程可以很容易地构建到AFM系统中，使用简单制造的电化学AFM探针和AA尺寸的干电池。该系统使我们能够减小图案尺寸，并对经过电化学处理的表面进行原位成像。此外，还展示了细胞伸展的原位定向控制。

The electrochemical-based biolithography technique was integrated into an ordinary atomic force microscope (AFM) configuration to pattern proteins and living cells. The patterning procedure could readily be built into an AFM system using a simply fabricated electrochemical AFM probe with an AA-size dry battery. This system enabled us to decrease the pattern size and to image the electrochemically treated surface in situ. Also, in-situ directional control of cell extension was demonstrated.