Pulmonary rehabilitation in chronic obstructive pulmonary disease with hyperinflation of the lungs

我们发现，在健康人受试者中，在高碳酸血症期间，呼吸困难和呼吸频率的阈值相似。阈值之间存在正相关。呼吸困难是慢性阻塞性肺疾病（COPD）的一个重要症状。肺过度膨胀是COPD患者的一种生理异常。它在运动过程中动态发展，导致呼吸困难的发生，从而限制了运动能力。根据我们的研究结果，在COPD患者中，由于呼吸急促的呼吸模式可能会减少呼气持续时间并导致空气滞留恶化，因此导致的呼吸困难可能会导致过度充气。然后，我们发现，通过一种新的设备，胸壁肌肉的触变性调节增加了COPD患者，特别是肺过度充气患者的剑胸骨区域的胸壁流动性。与此相反，这种调节降低了COPD患者在6分钟步行试验中呼吸困难的强度，而没有肺过度充气。

We found in healthy human subjects that the thresholds for dyspnea and respiratory frequency were similar during hypercapnia. A positive correlation was found between the thresholds. Dyspnea is a very important symptom of chronic obstructive pulmonary disease(COPD). Lung hyperinflation is a physiologic abnormality in patients with COPD. It progresses dynamically during exercise, contributing to the occurrence of dyspnea and thereby limiting the capacity of exercise. Based on our findings, the resultant dyspnea potentially worsens hyperinflation in COPD because tachypneic breathing patterns likely decrease the duration of expiration and lead to worsening of air trapping. We then found that thixotropy conditioning of chest wall muscles by means of a new device increased the chest wall mobility in the xiphisternal region in COPD patients particularly with lung hyperinflation. In contrast, this conditioning decreased the intensity of dyspnea during a 6-min walk test in COPD patients without lung hyperinflation.