Induction Mechanism of Genomic Instability Induced Independent of DNA Damage and the Implication on Carcinogenesis

非致突变致癌物苯的代谢产物对苯二酚（Hydroquinone，HQ）可通过染色体误分离引起杂合性丢失（洛）。HQ与微管蛋白相互作用，干扰微管形成过程中的聚合/解离，激活Hog 1-Swe 1形态发生检查点，提示HQ诱导的洛缺失与HQ的这些特性有关。利用该洛缺失检测系统，不同LET的铁离子束也通过同源重组诱导了洛缺失。

Hydroquinone(HQ), which is the metabolite of the non-mutagenic carcinogen, benzene, induced loss of heterozygosity(LOH), through chromosomal mis-segrigation. HQ interacted to tubulin, interfered valance between polymerization/dissociation during microtubule formation, and activated Hog1-Swe1 morphogenesis checkpoint, suggesting that LOH induced by HQ is implicated in these characteristics of HQ. By using the LOH detection system, various iron beams with different LET also induced LOH through homologous recombination.