Development of early diagnosis and therapeutic methods for peritoneal damage during peritoneal dialysis

在本研究中，我们开发了一种腹膜透析中腹膜损伤的早期诊断方法。使用两种不同分子量的标志物，成功地同时评价了透析液的除水能力和物质交换能力。此外，我们还成功地开发了一种利用质粒DNA和碳酸钙颗粒将基因转移到整个腹膜器官的方法。该方法在小鼠体内操作简单、有效、安全。

In this study, we developed an early diagnosis method for peritoneal damage during peritoneal dialysis. Using two marker substances having different molecular weight, we succeeded in evaluating both water-removing and substance-exchanging abilities of dialysis fluids simultaneously. Moreover, we successfully developed a gene transfer method to whole peritoneal organs using plasmid DNA and calcium carbonate particles. This method was simple, effective and safe in mice.