Molecular pathogenesis of the mucosal lesion due to the dysfunction of NHE3-CFTR transportsome

为了使胃肠道和呼吸道粘膜的防御机制正常工作，腔液的pH必须保持中性~碱性。本研究表明，含CFTR和NHE 3的细胞膜转运体在HCO_3 ~-的跨粘膜分泌中起关键作用。利用MATLAB/Simulink建立了HCO_3 ~-分泌的数学模型。将每个离子通道/转运蛋白/泵的动力学模型安装在模型细胞的基底膜和顶膜中。

For the defense mechanisms of gastrointestinal and respiratory mucosa to work properly, pH of the luminal fluid must be kept neutral～ alkaline. The present study demonstrated that the cell membrane transportsome containing CFTR and NHE3 plays a key role in transmucosal HCO_3^-secretion. A mathematical model of HCO_3^-secretion was constructed using MATLAB/Simulink. The kinetic model of each ion channel/transporter/pump was mounted in the basolateral and apical membranes of the model cell.