Analysis of expression mechanisms of neuroendocrine cancer cell-specific molecules via TTF-1

甲状腺转录因子-1（TTF-1）常在具有外周气道上皮样表型的肺腺癌中表达。然而，TTF-1的频繁和丰富的表达也被矛盾地发现在小细胞肺癌，这通常产生于中央气道。本研究的目的是探讨TTF-1的表达机制，寻找TTF-1调控的下游分子。研究结果表明，TTF-1的表达不受表观遗传学调控，而是与其他同源框转录因子和神经内分泌特异性碱性螺旋-环-螺旋转录因子协同复杂地调控基因表达。

Thyroid transcription factor-1(TTF-1) is frequently expressed in lung adenocarcinomas with peripheral airway epithelium-like phenotype. However, frequent and abundant TTF-1 expression is also paradoxically found in small cell lung cancers, which commonly generate from central airway. The aim of this study was to investigate the expression mechanism of TTF-1 and search downstream molecules regulated by TTF-1.Through this study, it was suggested that TTF-1 expression was not epigenetically regulated and that TTF-1 complicatedly regulated gene expression with other homeobox transcription factors and neuroendocrine-specific basic helix-loop-helix transcription factors cooperatively.