Adverse neurodevelopment in infancy associated with maternal smoking during pregnancy and genetic polymorphisms : exploiting gene-environmental interaction

吸烟的遗传易感性可能与不良的出生结果有关。为了估计怀孕期间母亲吸烟和遗传多态性对婴儿神经发育的影响，我们对分娩单胎活产的妇女进行了一项前瞻性出生队列研究。使用多元线性回归模型估计母亲吸烟和某些多态性与6、18和42月龄认知缺陷的关系。这些基因型与不良反应之间没有相关性。

Genetic susceptibility to tobacco smoke might have relation to adverse birth outcomes. To estimate the effects of maternal smoking during pregnancy and genetic polymorphisms on infant neurodevelopment, we conducted a prospective birth cohort study of women who delivered singleton live births. Multiple linear regression models were used to estimate the association maternal smoking and certain polymorphisms with cognitive deficits at 6, 18 and 42 months of age. There was no correlation between any of the genotypes and adverse effects.