Role of innate immunity and influence of smoking in the Pathogenesis of alcoholic pancreatitis

为了阐明酒精性胰腺炎的发病机制，我们建立了乙醇和脂多糖诱导的小鼠模型，并分析了先天性免疫和获得性免疫在该病中的作用。酒精性胰腺炎的发生发展离不开获得性免疫的参与。吸烟使疾病加重。诱导内源性抗氧化剂可改善胰腺炎，提示抗氧化剂治疗酒精性胰腺炎是有效的。

To clarify the pathogenesis of alcoholic pancreatitis, we created a murine model induced by administration of ethanol and lipopolysaccharide and analyzed the role of innate and acquired immunity in the disease. Participation of acquired immunity was indispensable for the development of ethanol-induced pancreatitis. Smoking aggravated the disease. Induction of endogenous antioxidants ameliorated pancreatitis, suggesting the usefulness of antioxidant therapy for the treatment of alcoholic pancreatitis.