Production mechanisms and roles of antibodies to glutamate receptor in ac ute encephalitis.

在非疱疹性急性边缘脑炎（NHALE）患者脑脊液中，GluRψ2（NR2B）和GluRζ1（NR1）抗体与临床进化有关。NMDAR抗体似乎内化了突触外的NMDAR，因为这些抗体可以阻止培养的大鼠神经元的凋亡。这些抗体似乎不整合突触NMDAR，因为它们不影响CREB（cAMP-Responsive-Element-Binding protein）的磷酸化。这些可能有助于NHALE相对较好的结果。

In CSF from patients with non-herpetic acute limbic encephalitis(NHALE), antibodies to GluRψ2(NR2B) and GluRζ1(NR1) we re related with clinical evolution. Antibodies to NMDAR seemed to internalize extra-synaptic NMDAR, because those antibod i es prevent ed apoptosis of rat cultured neurons. Those antibodies seemed not to inte rnalize synaptic NMDAR, because those did not affect phosphorylation of CREB(cAMP-Responsive-Element-Binding protein). These may contribute to the relatively better outcome of NHALE.