The effects of immature cells in the hypothalamus on food intake and weight gain

体重增加越来越被认为是非典型抗精神病药物的不良副作用。为了探讨这种副作用的机制，我们研究了奥氮平（一种非典型抗精神病药物）对成年小鼠下丘脑细胞增殖和分化的影响，我们发现治疗增加了下丘脑BrdU结合细胞的数量，而氟哌啶醇或对照组对细胞增殖的影响很小。双标记免疫组织化学显示，大多数BrdU阳性细胞也是Olig2或APC阳性，表明奥氮平治疗后产生了少突胶质细胞谱系细胞。这些发现表明，下丘脑胶质细胞生成与奥氮平治疗后体重增加之间可能存在联系

Weight gain is increasingly recognized as an unwanted side effect of atypical antipsychotic drugs. To explore the mechanisms underlying this side effect, we examined the effects of olanzapine, an atypical antipsychotic drug, on cellular proliferation and differentiation in the adult mouse hypothalamus.We found that the treatment increased BrdU-incorporating cell numbers in the hypothalamus, while the same regimen with haloperidol or control had little effect on cellular proliferation. Double-labeling immunohistochemistry revealed that the majority of the BrdU-positive cells were also Olig2-or APC-positive, indicating that oligodendrocyte-lineage cells were generated in response to olanzapine treatment.These findings suggest a possible link between gliogenesis in the hypothalamus and weight gain following olanzapine treatment