Experimental research on the pathogenesis and pathophysiology of diseases that cause dementia

大脑中异常蛋白质的积累被称为蛋白质病，是导致痴呆的神经退行性疾病的基本特征。异常蛋白积累的溶解是克服阿尔茨海默病和额颞叶变性等痴呆疾病的一种有希望的策略。本研究的目的是探讨蛋白质病变重叠，这是该领域尚未解决的问题。从蛋白病变重叠的角度对神经退行性疾病死后脑组织进行免疫组化分析。我们还制作了携带至少两个因素的小鼠模型，以便模型概括重叠的各个方面。

Accumulation of abnormal proteins in the brain, which is referred to as proteinopathy, is the essential feature of neurodegenerative diseases that cause dementia. Dissolution of the abnormal protein accumulation is a promising strategy to overcome such dementia disorders as Alzheimer's disease and frontotemporal lobar degeneration. The aim of this study is to investigate into the proteinopathy overlap, a yet unsolved issue in this field. We have analyzed immunohistochemically the postmortem brain tissues of neurodegenerative diseases from a view point of proteinopathy overlap. We also have made mouse models that carry at least two factors so that the models recapitulate aspects of the overlap.