A study of injectable osteoconductive bone substitute materials

磷酸八钙（OCP）晶体具有特殊的化学计量组成，对成骨细胞的分化和骨再生具有促进作用。合成的OCP晶体具有较高的生物相容性，有望成为一种人工生物可吸收材料。另一方面，基于陶瓷特性的脆性使得难以模制目标形状。在本研究中，我们创建了一个新的OCP材料结合透明质酸（Hya），这可以作为可注射的形式，并检查其在小鼠颅骨的骨再生性能。

Octacalcium phosphate(OCP)crystals, having particular stoichiometeric composition, have been shown to display a stimulatory capacity on osteoblastic differentiation and bone regeneration. Synthesized OCP crystals show higher biocompatibility and are expected to be an artificial bioabsorbable material. On the other hand, its brittleness based on the ceramics characteristics makes it difficult to mold the objective shape. In the present study, we created a new OCP materials combined with hyaluronan(Hya), which could be used as the injectable form, and examined their bone regenerative properties on mouse calvaria.