The approach to a trigeminal neuralgia mechanism based on a local GABA system hypothesis

本实验通过对三叉神经节细胞外GABA释放的显像研究了SC神经细胞神经传递调节的可能性，结果表明：在分散培养的条件下，神经元和SG均释放GABA，神经元的GABA释放可被GAT抑制剂抑制结果表明，在分散培养的条件下，神经元和SG均释放GABA，GAT抑制剂哌啶甲酸（Nipecotic acid）可抑制神经元GABA的释放，阴离子通道抑制剂（DNDS）可抑制SG的GABA释放。

We investigated possibility of the neural transmission regulation of the SC-nerve cell by imaging of extracellular GABA release at the trigeminal ganglion.As a result, GABA was released both from neuron and SG on dispersion culture, and the GABA release of neuron was inhibited by GAT inhibitor(nipecotic acid), and GABA release of SG was inhibited by anion channel inhibitor(DNDS).As a result, GABA was released both from neuron and SG on dispersion culture, and the GABA release of neuron was inhibited by GAT inhibitor(nipecotic acid), and GABA release of SG was inhibited by anion channel inhibitor(DNDS).