Research of prevention for urolithiasis considering gene and environmental factor, related metabolic syndrome.

尿石症在发生机制上看起来像代谢综合征。在此基础上，从遗传因素和环境因素两个方面对代谢综合征预防尿石症进行了研究。在遗传学研究中，我们分析了OPN基因的SNPs，并将其结果与患者的背景和结石成分进行了比较。我们发现特定的SNPs是结石复发的风险标志。在环境研究中，我们发现作为一种应激感受信号的核因子κB增加，线粒体受到氧化应激的损伤。

Urolithiasis looks like metabolic syndrome about mechanism of generation. Then, we performed research for establishment of prevention for urolithiasis by considering metabolic syndrome from genetic and environmental factors. In genetic research, we analyzed SNPs of the OPN gene and compared their results to patients' background and stone composition. We found the specific SNPs as a risk marker for stone recurrence. In environmental research, we found that NFκB as a stress receptivity signal was increased and mitochondria was received injury by oxidative stress.