Protection against respiratory infection during neonate to infant periods by maternal intranasal immunization

肺炎球菌疫苗在预防肺炎球菌感染方面起着重要作用。然而，婴儿表现出先天和适应性免疫反应受损，导致抗肺炎球菌抗体诱导不足。本研究结果表明，接种肺炎球菌表面蛋白a的母鼠所产的子代具有较高的抗肺炎球菌特异性抗体诱导率，这一结果将为肺炎球菌疫苗的开发提供一种新的策略。

Pneumococcal vaccine plays an important role in protection against pneumococcal infections. However, infants exhibit impaired innate and adaptive immune responses, which result in insufficient induction of anti-pneumococcal antibody. The current study demonstrated the highly induction of anti-pneumococcal specific antibody among offspring delivered from mother mice immunized with pneumococcal surface protein A. This result would conduce a novel strategy of the development of pneumococcal vaccine.