A study for the adherence of pathogens for the periodontal disease to the dental materials and for the inhibition effect of specific antibodies to the bacteria

对牙龈卟啉单胞菌(Porphyromonas gingivalis， P。使用从通用电气公司购买的GE ATKA plus。然而，我们无法获得大量的菌毛用于研究，然后，我们继续建立纯化菌毛的方法；因为在细菌致病机制的研究中，建立纯化菌毛的程序显然是必不可少的。在本研究中，我们发现纯化后的菌毛与细胞结合并诱导炎症细胞因子，另一方面，我们发现了菌毛抑制单核细胞样细胞凋亡的新的生物活性。

We have been purified the fimbriae of Porphyromonas gingivalis(P. gingivalis) by using GE ATKA plus purchased from General Electric Company. However, we can not obtain the significant amount of the fimbriae for research, and then, we continue to establish methods of purification of the fimbriae ; because it is clearly essential to establish the procedure of the purified fimbriae in the study of pathogenic mechanisms of the bacteria. It was demonstrated that the purified fimbriae bind to the cell and induced the inflammation cytokine, on the other hand, we found the new biological activity of the fimbriae that inhibit the apoptosis of the monocyte like cells, in this study.