Monitoring of social behavior associated with onset of hearing loss used model mice

为了积累听力损失后社会行为的基本数据，我们分析了F2小鼠在DBA/2J(D2，早发性听力损失模型)和C57BL/6J(B6，迟发性听力损失模型)之间使用的旷场活动。将F2小鼠分为听力正常组(NH组)和听力障碍组(HI组)，发现与NH组相比，HI组小鼠的听力保持在相同的位置。此外，HI小鼠在移动时间上比NH小鼠慢；这些结果表明HI小鼠通过听力障碍影响了自愿行为。通过QTL分析，我们在4号染色体上找到了与移动时间显著相关的QTL。此外，4号染色体标记D2/D2纯合子F2小鼠的运动时间明显慢于BALB/B6杂合子和B6/B6纯合子小鼠。

To accumulate the basic data of social behavior after onset of hearing loss, we analyzed open field activities using by F2 mice between DBA/2J(D2, model for early-onset hearing loss) and C57BL/6J(B6, model for late-onset hearing loss). The F2 mice were classified as groups of normal hearing(NH) and hearing impairment(HI), and we detected that HI mice significantly remained in the same place compared with the NH mice. In addition, HI mice were slower than NH mice in the moving time ; these results suggested that HI mice affect voluntary behavior by hearing defects. By QTL analysis, we identified QTLs on chromosome 4 that significantly associated with the moving time. Moreover, F2 mice of genotype D2/D2 homozygote at a marker of chromosome 4 associated with the moving times that were significantly slower than BALB/B6 heterozygote and B6/B6 homozygote mice.