Understanding and control of biodegradability of bioabsorbable Mg alloys

镁合金的降解性能取决于合金的种类，这与植入部位周围软组织中形成的气腔的数量有关。即使对于降解速度快的镁合金，也未观察到异常的炎症反应。当pH值超过细胞可接受范围时，由于降解过程中OH-释放引起的局部pH值升高可能会抑制细胞生长。用生物可吸收的医用聚合物包覆纯Mg，有效地降低了纯Mg的初始降解率，成功地提高了细胞相容性。

Degradation properties of Mg alloys depend on the kind of alloys, which relates to the amount of gas cavity formed in the soft tissue surrounding the implant site. Extraordinary inflammation was not observed even for the Mg alloy having rapid degradation rate. The local pH increase due to the OH- release accompanying the degradation may suppress cell growth when it goes over the acceptable range of cells. Coating of pure Mg with bioabsorbable medical polymers is effective to reduce initial degradation rate of pure Mg and successfully improves cytocompatibility.