Effects of nanomaterial exposure on cranial nerve system of offspring

本研究通过电镜分析、组织学分析、神经化学（单胺）分析以及基因表达分析，显示了母体暴露于纳米材料对后代脑神经系统发育的影响。结果表明，怀孕小鼠暴露于纳米技术中常用的纳米材料会导致子代发育期脑中微观结构、单胺及其代谢的改变。使用微阵列的基因表达分析显示了母体暴露于纳米材料对大脑发育影响的机制的重要线索。

The present study showed the effects of maternal exposure to nanomaterials on the development of cranial nerve system of offspring, using electron microscopic analysis, histological analysis, neurochemical(monoamine) analysis as well as gene expression analysis. The results indicated that exposure of pregnant mice to nanomaterial frequently used in nanotechnology induced alterations of microstructures, monoamine and its metabolism in the brain of offspring during the developmental period. Gene expression analysis using microarray showed an important clue of the mechanisms underlying the effects of maternal exposure to nanomaterials on the brain development.