Clarification of the genes involved in the hyperlipidemia and the application to the preventive medicine

为了阐明与高脂血症（高胆固醇血症）有关的基因，我们对在细胞内胆固醇转运和/或代谢中起重要作用的基因进行了功能遗传筛选。到目前为止，我们成功地从CHO细胞的大规模基因陷阱插入突变文库中分离出188个缺陷ldl -胆固醇摄取、细胞内胆固醇转运和/或代谢的突变体，并鉴定出49个已知基因和32个功能未知的基因。

To clarify the genes involved in hypelipidemia (hypercholesterolemia), we conducted a functional genetic screening of the genes that play an important role in intra-cellular cholesterol transport and/or metabolism. So far we succeeded to isolate 188 mutants that defected the LDL-cholesterol uptake, intracellular cholesterol transport and/or metabolism from the large-scale gene-trap insertional mutants library of CHO cells, and to identify the 49 known genes and 32 genes of unidentified function.