Novel radiation therapy with regulation of immune response

本研究的目的是开发基于放射免疫生物学的新型有效放射治疗（RT）。除了诱导细胞凋亡外，我们还研究了电离辐射通过对照射肿瘤和宿主的免疫反应介导的继发性抗肿瘤活性。当放疗后再进行细胞毒性T淋巴细胞治疗（CTL）时，由于RT抑制了髓源性抑制细胞的募集，CTL的抗肿瘤活性明显增强。我们证明了抗肿瘤免疫反应的调节有助于RT的改善。

The objective of this study is to develop novel effective radiation therapy(RT) based on Radiation Immunobiology. In addition to the induction of apoptosis, we investigate the secondary anti-tumor activity of ionizing radiation mediated by the immune response to the irradiated tumor and host. When RT was followed with cytotoxic T lymphocyte therapy(CTL), antitumor activity of CTLs was markedly enhanced by prior RT, because RT inhibited the recruitment of myeloid derived suppressor cells. We demonstrated that the regulation of anti-tumor immune response contributed to the improvement of RT.