Rapid and large scale production system of virus-like hollow nano-particles using Escherichia Coli

人乙型肝炎病毒包膜蛋白形成“病毒样中空纳米颗粒（hbsag样颗粒）”，是一种有用的生物材料，适用于疫苗、诊断检测载体和药物输送系统。以大肠杆菌为表达载体，建立了产粒体系，并对产粒进行了分析。结果表明，该生产系统减少了颗粒生产的时间和成本，并加速了新的有用颗粒的开发，如具有生物物质识别序列的颗粒。

Envelope proteins of human hepatitis B virus form "virus-like hollow nao-particles(HBsAg-like partiles)" which are useful bio-material applicable to vaccines, carriers for diagnostic tests, and drug delivery systems. We established the production system of the particles by using Escherichia Coli as an expression system, and analyzed the resultant particles. As the results, this production system decreases the time and cost for the particle production and accelerates the development of new useful particles such as particles displaying recognition sequences for living substances.