Surface modification of titanium by pack cementation process for improvement of bone compatibility

为提高钛的骨相容性，在钛表面制备了钙磷反应层，分别采用填充法、等压-等温法及两者结合的方法。反应层的物相为羟基磷灰石和Ca-P-O-Ti梯度层，厚度为数μm，细胞培养实验表明，反应层与基材的结合强度高，碱性磷酸酶活性高。这些结果表明，新工艺有效地改善了钛的骨相容性。

Calcium phosphate reaction layers were fabricated on titanium by pack cementation process, isobaric-isothermal process and their combination process to improve the bonecompatibility of titanium. The phase of the reaction layer was hydroxyapatite (HAp) and Ca-P-O-Ti graded layer, and its thickness was several μm. The reaction layer showed high bonding strength to the substrate and high ALP activity by the cell culture test. These results suggested that the new process effectively improved the bone compatibility of titanium.