Analysis of the relationship between chemosensitive responses of the cardiovascular neurons and hypoxia

本项目证明了心血管神经元对低氧具有化疗敏感性。为了探讨高血压的原因，我还建立了功能鉴定的心血管神经元在大鼠原位动脉灌流准备中的电流钳记录。我们还比较了正常血压大鼠和高血压大鼠心血管神经元的突触输入。结果表明，与正常血压大鼠相比，高血压大鼠心血管神经元的抑制性输入信号减弱。

This project demonstrated that cardiovascular neurons have chemosensitivity into hypoxia. In order to investigate into the cause of hypertension, I also established the current clamp recording of the functionally identified cardiovascular neurons in the in situ arterially perfused preparation of rats. We also compared synaptic inputs into the cardiovascular neurons in normotensive and hypertensive rats. As a result, it is suggested that inhibitory inputs into the cardiovascular neurons are attenuated in the hypertensive rats compared to normotensive rats.