Improved methods for quantitation of acute phase proteins in biological samples.

利用单克隆抗体和荧光极化，我们的目标是开发改进的定量分析方法，优于目前的临床分析。最初的目标将是c反应蛋白（CRP）和血清淀粉样前体蛋白（SAP），但该技术应易于适用于其他血清蛋白。更好的CRP和SAP检测将极大地促进对心脏病风险患者的临床管理，心脏病是澳大利亚医疗保健费用的最大单一贡献者。我们的进一步目标是调整这项技术，使其能够实现“即时检测”，帮助医生，特别是农村地区的医生，立即做出明智的诊断。

Using monoclonal antibodies and fluorescence polarisation, we aim to develop improved quantitative analytical methods that are superior to the current clinical assays. The initial targets will be C-reactive protein (CRP) and serum amyloid precursor protein (SAP), but the technology should be readily adaptable to other serum proteins. Better assays for CRP and SAP will greatly facilitate improved clinical management of those at risk of heart attack, the single biggest contributor to healthcare costs in Australia. We further aim to adapt this technology to enable "point-of-care" assays that would help medical practitioners, especially in rural areas, to make informed diagnoses immediately.