Effects of Japanese Kanpo on gastrointestinal motility disorders in inflammatory bowel disease.

汉歌-shashin-to（TJ-14）和Keishi-ka-shakuyaku-to（TJ-60）抑制大鼠远端结肠环行肌自发收缩的产生。一氧化氮的产生部分参与了这些抑制作用。TJ-14还抑制透壁神经刺激（TNS）诱导的阿托品敏感性收缩，表明TJ-14似乎对溃疡性结肠炎或克罗恩病的严重腹泻有效。另一方面，TJ-60对TNS引起的阿托品敏感性收缩的抑制作用较弱。因此，TJ-60可能对肠易激综合征有效，肠易激综合征导致与腹痛相关的复发性腹泻和/或便秘。

Hange-shashin-to (TJ-14) and Keishi-ka-shakuyaku-to (TJ-60) inhibited the generation of spontaneous contractions of circular muscles in the rat distal colon. The production of nitric oxide was partially involved in those inhibitory effects. TJ-14 also inhibited atropine-sensitive contractions induced by transmural nerve stimulation (TNS), suggesting that TJ-14 seems to be effective in severe diarrhea in ulcerative colitis or Crohn disease. On the other hand, TJ-60 showed weak inhibitory effect on atropine-sensitive contractions induced by TNS. Thus, TJ-60 may be effective in irritable bowel syndrome, which causes recurring diarrhea and/or constipation in association with abdominal pain.