Functionalization of the immediate loading implant by nano-materials and artificial proteins

钛等材料的表面改性在医学工程领域具有重要意义。我们正在使用我们的“碳纳米材料”和“基序编程人造蛋白质”方法来对钛的表面进行生物修饰。我们已经证明了DEX(地塞米松)-CNH对钛有吸引力的四种候选药物在一种新型的药物传递系统中的应用。地塞米松-CNH在哺乳动物细胞中显示出生物活性地塞米松的持续释放，没有明显的副作用。此外，我们成功地合成了含有嵌入细胞附着和钛结合基序的人工蛋白，并赋予钛细胞附着活性。

Modification of the surfaces of materials, such as titanium, is important in the medical engineering area. We are employing our "carbon nanomaterials" and "motif-programmed artificial proteins" methodology in order to biologically modify the surface of titanium. We have demonstrated that DEX (Dexamethasone)-CNH on titanium attractive candidates four use in a novel drug delivery system. DEX-CNH exhibited sustained release of biologically active DEX in mammalian cells without significant side effects. Furthermore, we successfully created artificial proteins that contain embedding cell attachment and Ti-binding motifs and endowed Ti with cell attachment activity.