Development of Innovative Methods for Analyzing Biological Molecules in Living Cells Based on Protein Chemistry

对活细胞中生物过程的化学理解对于科学的进步是极其重要的。该研究项目旨在开发新的分析方法，以解析活细胞中生物分子的复杂网络和功能。我们开发了1）分子探针来可视化活细胞中的生物功能，2）识别细胞内信号传导中特定分子的方法，以及3）分子探针来控制外部光的生物功能。这些探针和成像技术将在基础生物学和药理学领域的生物分子分析中发挥重要作用。

Chemical understanding of biological process in living cells is an extremely important for the progress of science. This research project aimed to develop novel analytical methods for resolving complicate networks and function of biological molecules in living cells. We developed 1) molecular probes to visualize biological function in living cells, 2) methods to identify specific molecules in intracellular signaling, and 3) molecular probes to control a biological function with external light. The probes and imaging technologies will be useful for the analysis of biomolecules in the fields of basic biology and pharmacological science.