Functional food to help reduce the risk of diabetic complications

甲基乙二醛（MG）是一种内源性代谢物，在糖尿病中增加，是美拉德反应（糖化）的常见中间体，与蛋白质反应并形成晚期糖化终产物。(1)利用mg修饰蛋白单克隆抗体，我们发现MGin可修饰肿瘤患者升结肠和直肠的热休克蛋白27 （Hsp27）。然而，mg修饰的Hsp25/Hsp27在非癌细胞系和正常受试者中未检测到。(2)在高糖条件下，许多茶提取物和抗氧化剂抑制了活性氧的产生和中性粒细胞的吞噬功能受损。可以预期，一些抗氧化剂可以预防糖尿病和炎症性疾病的发展。

Methylglyoxal (MG), an endogenous metabolite that increases in diabetes and is a common intermediate in the Maillard reaction (glycation), reacts with proteins and forms advanced glycation end products. (1) By using a monoclonal antibody to MG-modified proteins, we found that heat-shock protein 27 (Hsp27) was modified by MGin ascending colon and rectum of patients with cancer. However, MG-modified Hsp25/Hsp27 was not detected in non cancerous cell lines or in normal subject. (2) Many tea extracts and antioxidants inhibited both generation of reactive oxygen species and impaired phagocytosis in neutrophils under high glucose condition. It is expected that a number of antioxidant can prevent the development of diabetes and inflammatory disease.