Creation of polymeric contrast agent systems possessing multiple imaging modalities

在这项研究中，我们设计了基于聚合物的造影剂载体系统，可以应用于多种成像方式：MRI、PET、SPECT和超声。使用聚合物胶束MRI造影剂，我们成功地靶向了小鼠实体瘤，并在肿瘤部位获得了显着的图像对比度增强。此外，该聚合物胶束造影剂未显示任何ABC现象。由于ABC现象对多剂量造影剂有严重危害，这一事实表明聚合物胶束造影剂具有很高的临床应用价值。

In this study, we have designed polymer-based contrast agent carrier systems that can be applied in multiple imaging modalities;MRI, PET, SPECT, and ultrasound. Using a polymeric micelle MRI contrast agent, we succeeded in targeting to murine solid tumors and obtained substantial enhancementsof image contrast at the tumor sites. Additionally, this polymeric micelle contrast agent did not show any ABC phenomenon. Since the ABC phenomenon is seriously detrimental to multiple doses of contrast agents, this fact indicates a very high value of the polymeric micelle contrast agent in clinical use.