Localized surface plasmon sensing for detection and diagnosis of influenza viruses

建立了一种利用金属表面微观区域内的表面等离子体激元检测流感病毒亚型的方法。在这种方法中，折射率变化所产生的病毒和它们的单克隆抗体之间的相互作用进行了测量。理论计算表明，该检测区域半径约为180nm，可容纳约7种病毒。成功地证明了对某些亚型流感病毒的检测。

A method to determine subtype of influenza viruses by using surface plasmons localized in microscopic region on a flat metal surface was developed. In this method, refractive index variation arisen from interactions between viruses and their monoclonal antibodies was measured. Theoretical calculation revealed that measurement region had a size of ～180nm in radius, and could be occupied by ～7 viruses. The detection of influenza viruses with certain subtype was successfully demonstrated.