Elucidation of the metalloprotease-dependent onset of bloodcirculation

我们成功地观察到活斑马鱼胚胎红细胞循环的开始。结果表明，红细胞从血管中脱离是血液循环启动的必要条件，红细胞中表达的ADAM 8参与了这一过程，并且依赖于ADAM 8的红细胞-血管脱离也参与了血管的发育。在小鼠肌肉再生过程中，ADAM 8在炎性细胞如中性粒细胞和单核细胞中表达，这种蛋白酶是去除受损肌肉所必需的。

We succeeded to observe the onset of erythrocyte circulation in livingzebrafish embryos. We could show that the start of blood circulation requires detachment oferythrocytes from blood vessels, in which process ADAM8 expressed in erythrocytes participate.Moreover, erythrocytes-blood vessel detachment dependent on ADAM8 was involved in the bloodvessel development. ADAM8 is expressed in inflammatory cells such as neutrophils and monocytesduring muscle regeneration in mice, and this protease is required for the removal of injuredmuscle.