Pathogenetical and etiological study on biliary diseases with respect to embryological close relation and cellular similarities to pancreas

胆道和胰腺几乎同时起源于内胚层前肠，两者具有相似的组织和细胞结构及表型。根据这些相似性，对胆道疾病的病因和发病机制进行了研究。本研究中获得的数据总结如下。I）一些胆道和胰腺的炎性疾病，如IgG 4相关的硬化性疾病和酒精性胰腺炎和胆道疾病经常重叠，并显示出相似的病理特征。胰管腺癌和胆道癌包括其癌前病变显示相似的病理和表型特征。胰腺和胆道的导管内乳头状肿瘤也表现出相似的特征和表型。总之，本研究中基于胰腺和胆道之间的相似性获得的数据适用于胆道疾病的治疗方法。

Biliary tract and pancreas derive from endoderm foregut almost same time, and both show similar tissue and cellular structures and phenotypes. With respect to these similarities, the etiology and pathogenesis of biliary tract diseases were examined. The data obtained in this study were summarized as follows. I)Some of inflammatory diseases of the biliary tract and pancreas such as IgG4-related scloerosing disease and alcoholic pancreatitis and biliary disease were frequently overlapped and showed similar pathological features. II)Pancreatic duct adenocarcinoma and biliary tract carcinoma including their pre-neoplastic lesions showed similar pathological and phenotypic features. III) Intraductal papillary tumor of the pancreas and biliary tract also showed similar features and phenotypes. In conclusion, the data obtained in this study based on the similarities between pancreas and biliary tract were applicable in the therapeutical approaches of the biliary tract diseases.