Research on the marine sources for drug discovery in the tropical coral reef.

我们在印度尼西亚热带珊瑚礁进行了药物发现的海洋来源研究。2010-2013年，我们在万鸦岛收集了四次无脊椎动物，包括海绵和被囊动物。在2010年和2011年，我们从无脊椎动物中分离出真菌。我们在实验室进行了生物活性的筛选，如对泛素-蛋白酶体系统的抑制，细胞毒性和抗菌活性。我们成功地分离出抑制蛋白酶体、泛素系统中的E1、去泛素化酶USP7和体内抑制动脉粥样硬化的新化合物。这些结果在会议和期刊上报道。

We conducted the research on the marine sources for drug discovery in the Indonesian tropical coral reef. In 2010-2013, we collected invertebrates including marine sponges and tunicates based on Manado four times. In 2010 and 2011, we isolated fungi from the invertebrates. We performed the screening of the biological activities, such as an inhibition of the ubiquitin-proteasome system, cytotoxicity, and antimicrobial activity, in our laboratory. We succeeded in isolating new compounds that inhibited the proteasome, the E1 in the ubiquitin system, the deubiquitinating enzyme USP7 and suppressed atherosclerosis in vivo. Theses results were reported in meetings and journals.