Immunogenetic analysis of early onset schistosomal fibrosis in the Philippines

血吸虫后肝纤维化和肝硬化是对门静脉区卵沉积过度免疫反应的主要后遗症。在人类中，对控制肝脾疾病发展的免疫调节机制知之甚少。本研究的目的是确定菲律宾索索贡省早发性血吸虫肝纤维化患者中早发性血吸虫肝纤维化的患病率、不同宿主遗传因素和免疫反应背后的机制。在索索贡省伊罗辛市血吸虫病流行村，对受试者进行了加藤-卡兹大便检查、超声检查和抗sea抗体检测。免疫遗传学分析结果显示，早期发病血吸虫后纤维化患者的免疫应答受HLA-DRB1*15:01的限制，其进展与HLA-DRB1基因的表达水平有关。

Post-schistosomal hepatic fibrosis and cirrhosis are the major sequelae resulting from excessive immune response to deposited eggs in the portal area. In humans little is known about immunoregulatory mechanisms controlling the development of hepatosplenic disease. The objective of the study is to determine the prevalence of the early onset schistosomal fibrosis and the different host genetic factors and mechanism behind the immune responses in patients with early onset schistosomal liver fibrosis in the Sorsogon Province, Philippines. The subjects were subjected to Kato-katz stool examination, ultrasonographic examination, and detection of anti-SEA antibody, located in the schistosomiasis endemic barangays of the municipality of Irosin, in the province of Sorsogon. Results of imuunogenetical analysis showed measure immune-responses in early onset post schistosomal fibrosis was restricted HLA-DRB1*15:01 and progression was related on expression level of HLA-DRB1 gene.