Development of medical technology assessment methodology based on Bayesian statistics

自20世纪50年代建立临床试验方法学以来，显着性检验和估计一直是标准方法。这种方法被称为频域方法。近年来，贝叶斯统计已被应用于生物医学领域的复杂统计建模，并主要在癌症临床试验中提出了几种研究设计和序贯监测的方法。我们开发了基于贝叶斯方法的探索性临床试验的新设计。

Since 1950s in which the methodology of clinical trials was established, significance tests and estimation have dominated as standard approaches. This approach is called frequentist approach. In recent years, Bayesian statistics have been applied to compl ex stati stical modeling in biomedical field and several approaches to study design and sequential monitoring have been proposed mainly in cancer clinical trials . We developed new design for exploratory clinical trials based on Bayesian approach.