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Why have nematode a radiation tolerance? :Elucidation of the resistant mechanism.

Why have nematode a radiation tolerance? :Elucidation of the resistant mechanism.
为什么线虫具有辐射耐受性?
批准号:
22510064
负责人:
ISHII Naoaki
金额:
$2.83万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012

项目摘要

项目成果

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中文摘要
翻译
已知线虫具有很强的辐射耐受性。线虫C.线虫幼虫经历Dauer期,通过环境改革恢复正常期。中等剂量的X射线照射的dauer幼虫增加其postdauer寿命。结果表明,X射线照射后,与代谢调节/应激反应相关的代谢调节/抗氧化酶基因表达上调。特别是转录因子MXL-3在辐射耐受中起着重要作用
英文摘要
It is known that nematode shows strong radiation tolerance. In response to harsh environmental conditions, nematode C. elegans larvae undergo dauer stage and recover the normal stage by environmental reform. Modest doses X-irradiation of dauer larvae increased their post-dauer longevity. We founded that the gene expressions of some enzymes of metabolic regulation/anti-oxidation related with metabolic regulation/stress response were up-regulated in the X-ray irradiated dauer larvae. Especially, it is suggested that a transcription factor, mxl-3 plays a role of radiation tolerance
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DOI: 10.7143/jhep.39.519
发表时间: 2012
期刊:
影响因子: --
作者: [Y. Nishizaki, I. Kuwahira, A. Kubo, R. Tanino, N. Ishii]
通讯作者: N. Ishii
分子生物学的見地からみた放射線(電離放射線)とその健康影響
从分子生物学角度看辐射(电离辐射)及其对健康的影响
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [原のりこ, 榊原啓之, 小柳顯陽, 青島良輝, 山崎隼輔, 下位香代子, 石井 直明]
通讯作者: 石井 直明
老年医学 系統講義テキスト
老年医学系统讲座文本
DOI: --
发表时间: 2013
期刊:
影响因子: --
作者: [Toshio Fukusato, Masato Watanabe,Shunichiro Kubota, Akihiro Arima, Atsunobu Muneoka, Hiroshi Sumida, Mineo Yasuda, Onouchi H, Toshio Fukusato, 石井直明]
通讯作者: 石井直明
The Mechanism of Longevity with Hormesis by the Low Dose X-irradiation in C. elegans
低剂量 X 射线照射线虫的长寿与毒物兴奋效应机制
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Yan T, Matsuda S, Prieto Vila M, Mizutani A. Murakami H, Seno M, Hirao A, Seitaro Hayashi]
通讯作者: Seitaro Hayashi
共 35 条
    Elucidation of signal transduction pathway related to a radiation resistance of the nematode
    • 批准号:
      25340037
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.33万
    • 财政年份:
      2013
    • 负责人:
      ISHII Naoaki
    • 依托单位:
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    • 批准号:
      19500369
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.91万
    • 财政年份:
      2007
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    • 批准号:
      17500291
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
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    • 财政年份:
      2005
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    • 批准号:
      14580801
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $1.54万
    • 财政年份:
      2002
    • 负责人:
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    • 依托单位:
    海外基金