Inhibition of the morphine-induced tolerance and psychic dependence: Relation to vasopressin receptors

疼痛控制非常重要，因为，例如，即使是现在，仍有2000万人患有神经病理性疼痛。尽管许多基础科学和临床研究人员已经做出了努力来控制疼痛，但不幸的是，疼痛的机制还没有完全被了解。即使在今天，吗啡作为一种典型的阿片类药物，仍然是缓解剧烈疼痛的有用药物。然而，重复或持续使用吗啡和其他阿片类药物与止痛耐受的潜在风险有关，这需要增加剂量才能保持同样的疗效。因此，在这项研究中，我们研究了(1)神经病理性疼痛的机制和(2)对吗啡的耐受发展。本项目的研究结果可能为未来吗啡的临床应用提供新的线索。

Pain control is very important, because, for instance, even now 20 million people suffer from neuropathic pain. Although many basic science and clinical researchers have made efforts to control pain, the mechanism of pain is unfortunately not fully understood.Even today, morphine, a prototypical opioid, is useful medicine to relieve severe pain. However, repeated or continuous use of morphine and other opioids are associated with a potential risk of analgesic tolerance, which requires an increase in the dose to maintain the same efficacy. In this research, therefore, we examined (1) the mechanisms of neuropathic pain and (2) the tolerance development to morphineThe findings in this project may cast new light on clinical use of morphine in the future.